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We believed that the presence of these stimuli would lead to a more stringent selection of the relevant characteristic, and thus, a more efficient selection of shape, reducing the effect of the incidental conjunction of color.
However, preclinical studies of targeted drugs require a more stringent selection of animal models that accurately emulate human tumors.
This finding likely is consistent with a lower threshold for hospitalization in the control group, i. e. for a more stringent selection of patients needing hospitalization in the study group.
For genes with a high number of references (e.g. APP or APOE) a more stringent selection of abstracts is favorable, whereas for genes with a lower number of references a less restrictive search strategy might be beneficial.
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Owing to the limited number of APCs and the accessibility of MHCs and costimulatory molecules in vitro, a more stringent selection for activation may be imposed despite an excess of the galactosylated CII peptide.
Thus, the use of a more stringent selection criterion for the identification of homologous sequences did not decrease significantly the proportion of identified orthologous unigenes.
In addition to adding multiple new cancer sites to this analysis, and multiple new subgroups of cancers, we additionally used a more stringent selection criteria for cases and controls, based on amount and quality of genealogical data available.
RS analysis uses a more stringent selection process in which the actual enrichment score of each pathway is compared with the scores obtained by the permutation of labels an approach similar to that used in GSEA and with the scores for sets composed of randomly selected genes [ 17]. † No. of pathways found dysregulated by RS and GSEA with p-values < 0.05.
Although the results were better for the polyA+ RNA purchased from a commercial vendor, where a more stringent selection protocol was applied, we still find that > 50% of the intragenic reads map to introns.
Additionally, for a more stringent selection, all microRNAs can be removed whose expression level is close to that of the negative control features.
In order to investigate whether a more stringent selection strategy is beneficial, two selection campaigns were performed in parallel in rounds 4, 5, and 6: either 1 2% (stringent) or 5 8% (non-stringent) of the population were selected (Supporting information, Fig. S1).
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