The phrase "a more stringent cut off" is correct and usable in written English.
It can be used when discussing a stricter limit or threshold in various contexts, such as academic grading, eligibility criteria, or financial assessments.
Example: "The new policy requires a more stringent cut off for applicants to ensure only the most qualified candidates are considered."
Alternatives: "a stricter threshold" or "a tighter limit".
At a more stringent cut off level, still 63% of the sequences could be determined within ±10○C and 6% within ±5○C.
Since a 20% alteration in gene expression for many genes, such as transcription factors, can have dramatic cellular and biological responses [ 26, 32], a more stringent cut off (e.g. 2×) was not used in the current study.
As a result, we believe there is little significant biology lost by using a conservative cut off (consistent with literature precedent) of 0.125 (i.e., one mRNA per 8 cells) vs a more stringent cut off of 0.05 (one mRNA per 20 cells).
For this view we used a more stringent cut-off, based on the overall structural similarities of the 10,000 structures generated, and calculated separately for each sequence as follows.
The value of nHI/nH did not essentially change when a more stringent cut-off E-value was used (nHI/nH was 0.027 and 0.032 for the E-values of 1e-5 and 1e-10, respectively).
We expected that a less stringent cut-off (e.g., 40%) would allow too many negative sequences in the phyloPWM, and that a more stringent cut-off (e.g., 90%) would not introduce enough variability.
A more stringent cut-off was also used to identify strong rhythmic expression: pF24 < 0.05, F24 > 0.6 and amplitude > 1.75.
If a lower false positive prediction rate is preferred, a more stringent cut-off threshold (0.0-2.0) should be set.
First, each contig that included BAC clones with unlinked genetic markers was tentatively broken by re-assembling at a more stringent cut-off.
This reduction is again due to use of a more stringent cut-off used for whole genome de novo searches combined with use of updated genome assemblies.
Clinicians or researchers who administer a single test should opt for a more stringent cut-off and collect and analyze whole-brain volume.
