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Mooney and colleagues at the University of Hawaii, Kaneohe, tried for a more specific experiment--one that would directly test the effect on sonar on dolphin hearing.
CDC23 may be a mediator of miR-34c effects, but more specific experiments are needed to settle CDC23 as a direct miR-34c target.
Finally, more specific experiments lead to a better understanding of the mechanism by which active sites are formed under the action of Oso.
More specific experiments should be performed for a better understanding of the effect of Sal B on bone healing.
More specific experiments with molecular biological interventions are in progress to further examine the pathophysiology of DMD and test the long-term efficacy of PDE5I on adult mdx mice.
In any case, this observation has to be taken as preliminary only, and more specific experiments on the issue are planned using Real-Time PCR approach.
More specific experiments will be necessary to reveal how such small modifications of two to five residues could modify dynactin2's binding to Arp1, dynactin1, and dynactin3.
More specific experiments sought to determine the effect in mice on metastasis of B16BL6 melanoma of short-term and long-term exposure to 10percentand20percentcent w/v ethanol before and after intravenous inoculation into a tail vein or inoculation into the skin of the pinna of the ear 2 (Meadows et al. 1993 a, b ; Spitzer et al. 2000; Zhang et al. 2011 a ).
More recently in a nice series of experiments, a more specific inhibitor of Chk1 (AZD7762) was shown to potentiate the activity of both melphalan and bendamustine which did so with an accompanying increase Chk2 phosphorylation.
To validate these results, we undertook a more specific analysis and conducted in vivo experiments to assess the biological relevance of the five HU regulated clusters.
The use of conditional knockouts in mice may allow researchers to overcome this problem and test the role of genes identified thus far in high-throughput experiments in a more specific fashion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com