The phrase "a more sophisticated problem" is correct and usable in written English.
It can be used when discussing issues or challenges that require advanced understanding or complexity.
Example: "The initial issue was straightforward, but as we delved deeper, we realized it had evolved into a more sophisticated problem."
Alternatives: "a more complex issue" or "a more advanced challenge".
A more sophisticated problem outlined by Hodgson (1967: 38) and others is that a promising convention is broadly speaking incompatible with an act utilitarian society.
As the referees have pointed out correctly, it is one thing to show that Hop1 is a conditional regulator of Red1 deposition (this can be derived from the ChIP-seq data with high certainty), but a more sophisticated problem to compare two ChIP-seq profiles and scale them correctly, relative to each other.
These results demonstrate that the combination of the Wigner Monte Carlo method and Kohn Sham systems provides a reliable computational tool which could, eventually, be applied to more sophisticated problems.
Admittedly, there's a mounting frustration as each level becomes increasingly complex, demanding faster and more sophisticated problem-solving skills.
Financial advisors say the range of miscues run from the very basic like not starting or not adequately funding one of these tax-deferred plans to more sophisticated problems like tolerating higher-than-necessary fees or poorly allocating a portfolio.
I thought David Davis had a more sophisticated take on the problem when he addressed the conference fringe.
But if you present the same information from different perspectives, people become more open to learning and reach a more sophisticated understanding of the problem.
A more sophisticated approach to the problem of single examiners might seem to involve using the marks of other examiners at other stations.
Aside from all the obvious problems of inherent bias, he has to energise people by asking them to engage in the passive activity of watching him on television, has to ask for activism and a more sophisticated understanding of political problems through a medium that is all about voyeurism and simplification.
