Sentence examples for a more severe model from inspiring English sources

The lack of SVZ activation in our study could be due to the fact that the Batista study was examining R6/2 animals [5], which represent a more severe model, bearing a closer resemblance to juvenile-onset HD.

We also studied the role of NRG1 in a more severe model of nerve injury: sciatic nerve transection and reanastamosis (Supplementary Fig. 1B).

It would be interesting to repeat our experiment in a more severe model, investigating whether increased cholesterol-associated cartilage damage is detected.

We established a model of resolving peritonitis as well as a more severe model for comparison that progresses to systemic inflammation by injecting 2 distinct quantities of zymosan intraperitoneally into 2 separate groups of mice.

A more recent study has confirmed the efficacy of losartan treatment in improving aortic wall degeneration in Fbn1 mgR/mgR mice, a more severe model of MFS than the Fbn1 C1039G/+ mouse, even though the regimen showed no beneficial impact to counteract bone loss [ 49].

Whether this is the case for metabolic acidosis is unknown, it is reasonable however to speculate that in light of these data a rather more severe model would be required to demonstrate the protective effects of metabolic acidosis.

Furthermore, the ultrastructural abnormalities in mitochondria as well as intramitochondrial iron deposits were more frequent in the hFXNI154F mutants and a growth defect was only observed in this more severe model.

The "more severe" model inputs resulted in 3591 lost workdays (Table 2), with a loss of 9.3% of maximal capacity in the peak week and 2.9% over the six-week period.

We can further demonstrate the utility of the adaptive approach in situations of more severe model misspecfication.

12 Interestingly, in the more severe model, the eyes receiving saline injection whose fellow eye had received a bevacizumab injection had a better outcome than those eyes that received a direct ranibizumab injection.

In the more severe model of OA, anterior cruciate ligament transection (ACLT) with partial medial meniscectomy (ACLT+MMx), the medial collateral ligament was additionally transected with resection of medial meniscus.