The phrase "a more severe course" is correct and usable in written English.
It can be used when discussing a situation that requires a stricter or harsher approach or action.
Example: "Given the circumstances, we may need to take a more severe course of action to address the issue effectively."
Alternatives: "a stricter approach" or "a harsher path".
If established asthma is present, secondhand tobacco smoke is associated with a more severe course [ 5].
In immunosuppressed patients infection with mixed HCMV populations was associated with a more severe course of infection.
A higher incidence of IUGR in this group suggests a more severe course of the experienced pregnancy complications.
Some evidence suggests that individuals with bipolar spectrum disorders (BSD) generate stressful life events, contributing to a more severe course of disorder.
Impulsivity is substantially higher in bipolar patients (BP) and may be associated with a more severe course of illness, but no studies have so far examined the relationship between impulsivity and functional outcome in BP.
To investigate a previously reported observation that the presence of diffuse, as compared with localized, fundus flecks is an indicator of a more severe course for visual acuity (VA) loss beyond 20/200 in patients with Stargardt's disease.
The objective of this study was 2-fold: first, to determine whether the presence of multiple antibodies predicts a more severe course than single antibodies and second, to determine the utility of the Queenan curves/protocol in evaluating multiple-antibody isoimmunization.
Alternatively, those who are more impulsive may have a more severe course of illness.
This gives some support to impulsivity as a trait which may lead to a more severe course of illness.
Furthermore, impulsivity in bipolar disorder (BD) has been linked to poorer outcome, including a more severe course and suicidality (Watkins and Meyer 2013; Swann et al. 2009a).
Additionally, self-reported impulsivity seems to be higher among bipolar patients, both parameters being possibly associated with a more severe course of illness.
