In contrast to the OAK, the performance of the Flexible OAK does not recover immediately, indicating a more severe cause of the decreased reliability.
A more severe cause for the breeding deficiency of NHERF1 females appeared related to offspring survival after birth.
These neurobiological changes may point to an increased risk of bipolar disorder, and a more severe cause of the illness, since childhood trauma possibly may lead to disturbances in affective regulations [ 15, 30].
Furthermore, among children with an ongoing asthma, secondhand tobacco smoke exposure is considered to cause a more severe course [ 5].
It is also possible that changes in the immune system during this time cause a more severe course of disease.
Of the more severe causes, several have been greatly reduced by vaccination programs.
The recurrent type represents 50-75% of the cases in primiparous women, tends to have an early onset, is more severe, causes preterm delivery and other fetal and maternal morbidities, has more familial aggregation, and is associated with unvarying risk factors (environmental or genetic) that confer a risk of around 30% in each pregnancy in that particular group of women.
However, access to primary or secondary care differs, since general practitioners are often the first point of contact, whereas secondary care physicians are consulted by those patients who suffer from more severe symptoms, who do not recover or in whom general practitioners suspect a more severe underlying cause of disease.
Croup is diagnosed on clinical grounds, once potentially more severe causes of symptoms have been excluded (i.e. epiglottitis or an airway foreign body).
In contrast to Slovenia, Croatia, and Bosnia-Herzegovina, where a milder HFRS caused by PUUV and a more severe form caused by DOBV have been reported (4, 5 ), no severe forms of HFRS have been observed in Estonia thus far.
Tension-type headache is usually characterised by a mild pain intensity, normal or slightly reduced activities and no accompanying symptoms, while migraine is a more severe pain, causing reduced activity/bed rest and is accompanied by photo- and phonophobia, nausea and sometimes vomiting.
