They detected no live virus or antigens to the virus, but when they used a more sensitive screen--the polymerase chain reaction--they managed to pull fragments of the Ebola genome from seven animals: one shrew and six rodents from three different species.
If we would have used a more sensitive screening approach for PTB with a combination of symptoms as entry point for PTB (any cough, any fever or night sweats, or weight loss [31] [34] without specifying the duration of cough as Cain et al. [35] suggest, these patients would likely have ended up in the PTB track.
Using a more sensitive screening criterion (blood glucose > 130 mg/dL), > 20% had impaired GTT results.
A more sensitive screening instrument such as the Montreal Cognitive Assessment could be used in place of the MMSE [ 50].
A more sensitive screening-modality such as FFDM may also lead to an increase in the detection of biologically high-risk tumors as assessed by the 70-gene signature.
Kang et al. [ 36] concluded that a more sensitive screening can be achieved by testing the DNA methylation status of some genes, including MGMT, than by analyzing fecal blood.
With human papillomavirus (HPV) emerging as a more sensitive screening test for cervical cancer, there are opportunities for low and middle income countries (LMIC) to employ this technology to prevent cervical cancer morbidity and mortality.
By way of contrast, we have also estimated that introducing a more sensitive screening test (such as primary HPV testing) in women aged 25 64 could prevent 168 cancers per 100 000 women (even without changing the coverage) (Castanon et al, 2013).
Nevertheless, since screening will detect more cancers at an earlier stage, which is typically associated with lower treatment costs compared to cancers with a poorer prognostic index (Johnston, 2001), further cost savings are likely to be realised with CE MRI as it is a more sensitive screening modality.
A more sensitive screening by quantitative real-time PCR revealed that the mean relative expression level of transcript A was significantly lower in the high-stage tumours (mean 0.07; s.d. 0.03) than in the low-stage tumours (mean 0.35; s.d. 0.17) (P=0.1722).
