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A more rigorous demonstration of this requirement is still an open matter, and indeed rigorous proofs that particular solution types can only occur when three (or more) timescales are present have not, to our knowledge, been provided in the literature to date.
A more rigorous demonstration that cohesin interacts topologically with DNA came from experiments where all three interfaces in the cohesin ring were covalently sealed either by use of fusion proteins or the introduction of side chains that allowed specific chemical cross-linking of cohesin subunits (Haering et al. 2008).
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However, whilst the BBBS-M program performs well in this regard and is highly regarded by stakeholders, its sustained funding requires more rigorous demonstration of its effectiveness and cost-effectiveness.
Professional grade, year of experience, and annual caseload can be used as markers, although a more rigorous standard of direct demonstration of surgical competency has also been proposed (for example, providing training and supervision before participation).
The TETD included a much larger sample of beneficiaries than did STETS (745 versus 467) in 13 demonstration communities, which allowed for a more rigorous evaluation of program impacts.
A more rigorous discussion of jittered sampling.
A more rigorous test may prove more practically useful.
It will be revised next year after a more rigorous examination.
Other schools are taking a more rigorous approach.
Women just have a more rigorous time physically than men.
Towards a more rigorous definition of brain death?
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