The benefits of an increased sample size outweigh the disadvantages, through developing a more reliable sampling group by combining the two subgroups.
For more reliable sample sizes, patients were merged into three Gleason score groups: Gleason score 6 to 7, 8 and 9 to 10.
However, the numbers so far indicate that students who opt in for a MOOC do achieve higher final grade, particularly when having in mind the larger proportion of learners taking MOOC in years 2015/2016 and 2016/2017, i.e. more reliable sample.
This bias may overestimate the results and further research should expand to reach a wider population, with more reliable sampling techniques.
A more reliable control sample with which to improve the batch-correction might be provided by an mRNA sample more representative of that under investigation; in this case, a pool of tumour RNA rather than the UHRR.
An updated ω means an updated classifier, which is expected to be more trustworthy than previous ones, since it is trained with more reliable samples.
Further analysis showed that the filter system, which concentrates cells from very large volumes with consequently more reliable sampling, produced samples that were more consistent than the independent non-filtered samples (benchtop controls), with a logarithmic dependency on increasing cell numbers.
Therefore, using multiple assays based on different antioxidant mechanisms would be crucial in providing a more reliable assessment of the samples antioxidant capacity [ 4, 24].
Percutaneous needle biopsies under CT guidance are therefore suggested to be a more reliable method for targeted sampling of tissue probes, narrowing the information gap between non-invasive and traditional autopsy [ 27].
Considering also that the ESEM presented a more reliable factor structure for our sample, we adopted the ESEM factor structure for the subsequent analyses.
