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When compared to the historic fibre removed from a sample area in poor condition, this peak is mainly dominated by the presence of CA indicating full conversion towards this product and a more progressed state of oxidation [12].
These data also indicate that caution must be taken in treating human SS with therapies targeting the ICAM-1/LFA-1 interaction, since it is likely that most patients are diagnosed and request treatment in a more progressed stage of the disease.
Therefore, the overexpression of ER-βin CAsE-PE cells may also suggest a more progressed state.
The logic of that analysis would be sound if the MCI population was simply a more progressed version of the control population and the AD population were just a more progressed version of the MCI population.
A dramatic weight loss in a patient with pancreatic cancer may hint at a more progressed or more aggressive tumour.
Patients with clinical events were found to be more frequently diabetic and presented with a more progressed coronary atherosclerosis.
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In fact, during the CA/CD cross-validation experiments (a potentially more progressed state of oxidation) the artificially light aged fibre samples occasionally appeared as outliers.
Asian women presented with a larger tumour size, more progressed to a diagnosis of invasive carcinoma, and more had mastectomies compared to Caucasian women.
Although these differences do not reach statistical significance, in at least three instances, a 6 12 months more progressed cohort received the hypothesised inferior therapy (37, 39, 44).
Pancreatic cancer patients with cachexia had a higher rate of more progressed tumour stages and a worse nutritional status.
19 Furthermore, Bachmann et al. showed that pancreatic cancer patients with cachexia had a higher rate of more progressed tumor stages and a worse nutritional status.
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