In being sensitive to reward timing, amygdala neurons process a fundamental characteristic of reward function and thus may play a more profound role in reward than hitherto known.
This observation suggests that ΔΨ has a more profound effect on the function of the Fo motor than ΔpH.
It is possible that, in septic shock induced inflammatory response, a more profound depression of myocardial function and compensatory vasomotor reflexes takes place [ 30].
The broader role of SF1+ neurons revealed by our loss-of-function experiments may reflect the fact that genetically targeted ablation (Yang et al., 2013) causes a more profound elimination of SF1+ neuronal function than does chemogenetic inhibition, whose extent and efficacy in vivo is difficult to assess.
It is known that targeting key nodes has a more profound effect on the inhibition of deregulated functions that the inhibition of single receptors [ 28].
A more profound understanding of many of the immunomodulatory functions of CHI3L1 has long been hampered by the lack of identification of a receptor that could mediate the signaling.
Detailed and quantitative information about the location and concentration of the drug and carrier can be obtained as a function of time, thereby enabling a more profound understanding of biological effects.
It is conceivable that in a more compromised background, such as impaired EHMT1/EHMT2 function through BIX-01294 would have a more profound effect on reversal of epigenetic control in synergy with histone deacetylases (HDACs) and DNMT inhibitors [ 6].
On the other hand, patients with chronic renal failure due to graft failure have a poorer renal function at the time of dialysis reinitiation, and a more profound anaemia [ 7].
However, the miR-17∼92 miR-17∼9206b∼25 clusters shand overlapping functions since mice with combined deletion exhibit a more profound phenotype than those laclustersR-17∼92 alone (Ventura et al., 2008).
But a more profound issue is the proliferation of apps the mini programs required to perform every function with the iPad.
