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A more precise staging system for early-stage disease patients is required.
Because fish developmental growth rates strongly depend on breeding conditions (e.g., temperature, density, food quality) and therefore could vary among research facilities, we chose to use a more precise staging system proposed by other authors (Parichy et al., 2009; Sire et al., 1997) using larvae length as an index of development instead of dpf.
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Therefore, it is extremely important to reach an accurate diagnosis, which can facilitate more precise staging and prognostic estimations, as well as evaluation of response to therapy.
Moreover, developmental landmarks, including hatching, larval molting, mounting, spinning, pupariation and eclosion, were employed for more precise staging.
For instance, the discovery of signature genes for breast cancers through microarray analysis of gene expression has provided us with a more precise clinical staging that will improve the outcome of treatment [ 20, 21].
Without specific stage and viability markers, it is impossible to attribute a more precise developmental stage and viability condition to individually selected IRBCs under confocal observation.
These results showed that ICN1 expression might add some prognostic information for patients with gastric cancer and lead to a more precise classification integrated with TNM stage.
The underlying hypothesis was that the higher accuracy of gadoxetic acid-enhanced MRI of the liver would lead to a reduced need for additional pretherapeutic staging examinations, a more precise surgical plan, and thus fewer instances of intraoperative modification of the plan designed before surgery.
In order to increase the accuracy in the pipeline stage delay estimation, a more precise technique is required that takes into account the operation implementation methods.
A more elaborate specification of the two-stage-model, including a more precise description of the terms in model (2), is provided in Piepho et al. (2012a).
This also outlines the interest of unbiased massive parallel sequencing methods for a more precise clinical diagnostic in case of end stage disease.
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