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As a result, SB216763 may act through a single target and have a more moderate effect on Hsp72 levels.
shRNA Rab27a #313, #735 and #865 completely silenced Rab27a, while shRNA Rab27a #477 yielded a more moderate effect (Fig. 4A).
Interestingly, IDC16, which has been shown to inhibit efficiently ex vivo replication of HIV-1 [13], had a more moderate effect on F-MLV replication, suggesting that requirements for SR proteins vary with the retrovirus type.
Generally, we observed that vorinostat had a more moderate effect on protein trajectories than TSA.
Thus, we confirmed our previous conclusion that vorinostat has a more moderate effect on protein mobility than does TSA.
In contrast, we show here that vorinostat had a more moderate effect on protein mobility than TSA.
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A much more moderate effect was observed with AMD3100, indicating differential efficacy between these two inhibitors.
A similar, if more moderate effect of NZO is evident for HDL cholesterol.
It is likely that a number of other susceptibility loci of more moderate effect sizes exist and these may only be revealed through combining data or meta-analysis to generate sufficiently large sample sizes to be confident of identifying their effects.
More moderate effect sizes were evident for internalizing symptoms (g = 0.74), self-appraisal (g = 0.63), externalizing symptoms (g = 0.52), and sexualized behavior (g = 0.49), while small effects were found for measures of coping/functioning (g = 0.44), caregiver outcomes (g = 0.43), and social skills/competence (g = 0.38).
More refined manipulations of Nadrin2 have a number of more moderate effects: it shows a mild (50%) enrichment in actin patches along the dendrite compared to GFP, and its knockdown prompts an increase in the number of quickly collapsing protrusions and a 20% increase in steady state filopodia density.
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