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These abundant microRNAs may therefore play a more important functional role in regulating cellular processes connected to Dupuytren's disease pathogenesis than microRNAs with low levels of expression.
It is also possible that other CLs make a more important functional contribution than CL3 does, although the model shown in Figure 1 suggests a fairly symmetrical contribution of all four CLs to the apparent central pore.
In contrast, PTH which in teleosts and Xenopus appears to be a paracrine factor seems to have gained a more important functional role during evolution and became a major endocrine factor with a restricted production in a highly specialized structure, the parathyroid gland [ 34].
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An increased percent identity in a genomic region may indicate more important functional elements (stronger purifying selection) rather than a larger number of functional elements residing in that region.
Selenoprotein loss does not seem to have greatly influenced their evolutionary rate, and they are therefore likely to have additional (and perhaps more important) functional roles not directly related to selenoprotein biosynthesis.
Taken together, these data suggest that obese COPD patients might have more important functional impairments.
Hence, we speculate that orthostatic intolerance in POTS may be a more important determinant of functional impairment than fatigue.
Because the repertoire of invertebrate accessory subunits is more limited than that of vertebrates, the utilization of BAF and PBAF subunits may play a more important role in the functional diversity of invertebrate SWI/SNF complexes.
While these methods have mostly been used to detect and identify structures visualized in cryo-ET or to assist the search for a feature of interest, we expect that in the future they will play a more important role in the functional interpretation of cryo-tomograms.
Rather, a more important parameter appears to be the functional competence of sperm cells – since this cannot be evaluated using a single variable, researchers have proposed that semen samples should be subjected to multi-parametric analysis [ 1- 3].
Individuals with several or serious chronic diseases have a high mortality and they generally have already died at a younger age. Lee and colleagues [ 16] showed that chronic conditions have lessened the predictive value of mortality among the oldest-old, hence the functional status was a more important predictor of mortality.
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