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Once developed, these exposure indices must be validated by using a more direct exposure assessment method such as biologic or environmental monitoring.
These data will allow calculation of analyte excretion rate and permit evaluation of potential associations with health outcomes on the basis of a more direct exposure metric as well as on the basis of urinary concentration.
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Individual investors have a handful of ways to gain more direct exposure to hard assets like gold, copper or oil without the risk of trading individual commodity futures contracts.
The exact strategy for exposure monitoring directly depends on the study design; for example, if the study design is a long-term longitudinal cohort study of 100,000 children, fewer direct (e.g., biomonitoring) exposure measures may be collected for each child; but if it is a series of smaller nested case control studies, more direct exposure measures can be made.
Commercial fishermen claim that if lobster traps are fished in linked sets, or trawls, that the trap that is adjacent to the surface buoy generally has a lower catch, presumably because of increased trap movement due to more direct exposure to wind influence.
Other established peri traumatic risk factors for PTSD such as physical injury [ 5], exposure to dead bodies [ 26] and perceived life threat [ 5] are theoretically more likely with more "direct" exposure such as being present at the time of a bombing compared with less direct exposure witnessing the immediate aftermath of a bomb.
Italy is not the only European country to have strong reservations about Mr. Haider, but it has more direct exposure.
Healthcare workers and contacts have had greater and more direct exposure to influenza cases compared to the general population and this first-hand experience may have resulted in behavioral changes.
Those young people who reported a more direct physical exposure to the bombing were significantly more likely to score above the caseness threshold.
But public health specialists have long been concerned about more direct exposures to mercury for the miners themselves, who inhale vapors when they burn off mercury they have used to amalgamate gold during the recovery of the precious metal.
One implication of finding a much stronger association of wheeze with airborne endotoxin than with dust endotoxin in the family room is that it is reasonable to assume that airborne endotoxin measured over 1.5 days is a more direct measure of exposure than is dust endotoxin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com