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The phrase "a more difficult issue" is correct and usable in written English.
It can be used when discussing a topic or problem that is more challenging than another.
Example: "While the initial problem was manageable, we soon encountered a more difficult issue that required further analysis."
Alternatives: "a tougher problem" or "a more complex matter".
Exact(29)
A more difficult issue is as to the tugs.
Whether it should be a crime is a more difficult issue.
(How to achieve that with our present political and media culture is a more difficult issue).
Whether the order to repay Morgan Stanley a portion of Mr. Skowron's compensation is a more difficult issue.
"It's a more difficult issue for them to raise successfully on appeal because of that narrow focus," Mr. Biros said.
Terrorism is a more difficult issue, if only because the consequences of a terrorist attack are more severe than those of corruption.
Similar(31)
That is a much more difficult issue; one study found that backing the worst fund managers of the previous five years was more profitable than backing the best.A new academic paper approaches the subject from a different angle.
"I can tell you I've watched him deal with a far more difficult issue last year," Maurice said, referring to the death from cancer of his wife's sister.
Stopping global warming seems like a good idea, but that is not quite the same problem, and is a far more difficult issue on which to reach consensus both in the West and in Asia.
"They're finding it to be a lot more difficult issue than they ever thought it would be," he added.
Secondary-structure prediction programs (Rost, 2001) could be used to find β-strands, but determining how they are paired and hydrogen bonded is a much more difficult issue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com