Clearly, IGF1, FGF2, and BMP2 trigger separate responses in the cells; IGF1 leads to increased expression of all genes analysed, however, the other two growth factors showed a much subtler and more differentiated response.
One knew a more differentiated, polarized response would come later.
However, responses to close-ended statements focused on potential social and material advantage from volunteering generated more differentiated responses.
Cells with concurrent BRAF mutations and melanocortin 1 receptor germ line variants and/or a more differentiated melanocyte genotype had a preferential response.
That said, in agreement with our finding that a more differentiated HIV-1 specific CD8+ T cell response is associated with higher CD4 counts two recent clinical studies have suggested that more differentiated CD8+ T cell responses are associated with lower HIV-1 viral load set point, or long-term non-progressor status in HIV-1 disease [10], [11].
A more differentiated, less activated HIV-1 specific CD8+ T cell response may be clinically protective.
NKG2A+CD57+CD56dim cells may be in an intermediate differentiation phase, retaining responses to cytokine stimulation and in transition to a more differentiated phenotype [24].
Also, owing to the tremendous growth in the range and clarity of a child's response capabilities, assessments of preschoolers and older children generate a more differentiated picture of a subject's developmental strengths and weaknesses.
Speaking during a visit to Berlin by the Russian president, Vladimir V. Putin, Mr. Schröder said: "Regarding Chechnya, there will be and must be a more differentiated evaluation in world opinion".
In fact, the secular trend across European states is for a convergence around a more differentiated system of strategies toward protests.
