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One can speculate that it may 'specify' a type of breast cancer progenitor cell, perhaps a more differentiated one that shares morphological or biological features with alveolar cells.
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This data points to the conclusion that in the poorly differentiated HCC cell line, the efflux is mainly depend on the ABCG2 activity while in the more differentiated ones, drug export is also accounted by the activity of ABCB1.
It has been shown that highly proliferating malignant cells have less gap junctions than more differentiated ones (Yamasaki and Naus, 1996).
Gene duplication might also have happened in an ancestor of the Deinococcus-Thermus group, which is likely to have carried two members of the LytR-CpsA-Psr family: one of the M cluster-type and a more differentiated, phylum-specific one.
Cells exhibited a more differentiated phenotype on the PEGDMA DEGDMA copolymers compared to the 2HEMA PEGDMA copolymers.
We have long argued that the West, as it were, should take a more differentiated view on power.
One knew a more differentiated, polarized response would come later.
Our model describing one of these physiological ROS effects can account for a more differentiated understanding of real ROS effects on ageing.
On one hand, primary cells have a more differentiated phenotype compared with cell lines.
Paradigm shift from one-sided analysis of caregiver burden to a more differentiated view of the situation of the caregivers is new (Bauer et al. 2012b).
On the dimensional level, we found a more differentiated picture.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com