Inhibition of furin decreases tumor growth in some preclinical tumor models [28], [29], [30], while other tumor models indicate a more complex contribution of PCs to tumorigenesis [31], [32] Thus, although the dual role of PCs in tumorigenesis has to be further investigated, PCs represent a promising target to decrease or even prevent the activation of cancer-promoting factors [33].
"Our genomewide approach, I feel, is better; [it] suggests a more complex origin with contributions to the dog genome from the Middle East, Europe, and Asia that reflect possible multiple origins and a history of [interbreeding] between early dogs and wolves," Wayne says.
Alternatively, the pH modulation by the OCA2-mediated Cl− conductance could be a more complex mechanism involving the contribution of additional channels and transporters.
For recent admixture in the single-admixture model, or in a model with continuing admixture after the founding of the admixed population, the mean admixture fractions from S 1 for the X chromosome depend on the sex-specific contributions in a more complex way, incorporating the sex-specific contributions from S 2 (Equations 12, 13, and 17 20).
Next we constructed a more complex multi-branch lattice reflecting contributions of the transcriptional regulators Mot1 and NC2 to the two-branch model involving TFIID and SAGA (Figure 2).
This may be due to different sets of functional variants residing in the same haplotypic backbone and leading to different biological outcomes resulting either in a primary tauopathy vs. tau pathology in LOAD; a more complex genetic architecture in LOAD with contribution from multiple functional variants in different pathways; or a combination of both.
We could develop a more complex probability model allowing for the primer contribution and utilize the full data set.
Mr. Darton's book, also published in 1999, is a more complex undertaking, more polemical and, while an interesting contribution, less accessible.
This can result in a more complex pattern of interfacial dislocations and may have a significant contribution to the interactions between threading and interfacial dislocations.
In this issue, Felzer and Brodsky (page 735 1 try to pin down the relative contribution of some of these effects in a more complex context: the triggering of earthquake aftershocks.
Further, much like the slow but steady evolution of mainstream EDM, social media's contribution to music marketing over time has gone from "all noise is good noise" to a more complex affair.
