We expect that our model will be a useful contribution to the pathway community, making possible the creation of more practical and more complete pathway representations that will be both more end-user friendly, as well as better suited for advanced computational analysis.
This tool is currently being applied in a routine clinical setting in the context of a phase 3 clinical trial, and the BDC tool developed in this work could be applied with this to provide a more complete diagnostic pathway in routine clinical practice.
Multiple measurements in the pathway, including those that are less dependent on the tissue preservation methodology, should give a more complete picture of pathway status and have greater utility as prognostic or predictive biomarkers.
(Xylem-feeding insect symbionts, on the other hand, survive primarily on a water diet and retain a more complete oxidative phosphorylation pathway and, likely, larger genomes overall).
Novel enzymes, biochemical mechanisms, and metabolic pathways have been discovered, resulting in a more complete description of methylotrophic pathways and their diversity.
In addition to the apicomplexans, searches were also extended to include dinoflagellates and ciliates to gain a more complete picture of the pathway among alveolates.
Since knockdown of MT1-MMP itself can affect invadopodium dynamics (Fig. 6), a more complete block of the pathway with ILK-KD might lead to the difference that we noted for invadopodium dynamics.
We believe that the classification performance of the pathway-based methods will be considerably improved once we have a more complete list of biological pathways.
This underlines that solar activity influences Earth processes and argues for a more complete analysis of the pathways through which this happens.
A more complete understanding of these pathways can therefore be useful in developing therapies or medical devices to correct such deficits.
Future studies should aim to provide a more complete understanding of the pathways that preserve and repair alveolar growth during injury, which might be translated into novel strategies to treat lung diseases in infants and adults.
