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The company also faces a more basic challenge associated with participating in Internet transactions: fraud.
A more basic challenge, Dr. Marburger added, will be helping the government to brainstorm to make sure it was "covering everything you need to do to protect yourself" against terrorism.
Those same factors will also determine whether we see next a further shift to trickle-up economics – or a more basic challenge to an economic system whose instability is so severe and so socially costly.
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But these same women, who risked their lives for the safe future of their children, are struggling with a much more basic challenge: providing food for their families.
But this belies the more basic challenge of creating a proper venture-capital industry.
The more basic challenge is to prevent the pressure of a sleepless Internet and a furious partisanship from taking the kind of toll that probably helped cut short Breitbart's life, long before what should have been his time.
He went on to explain that while this was actually "part of the vision from the beginning," it took longer to add because the more basic challenge of making good task management was bigger than they thought it would be.
"We had no idea how to even approach this character; how do you make it appealing from a design standpoint in terms of making it a character people would feel was approachable and likable, fun to watch on the screen and can deliver a performance?" The team had to figure out even more basic challenges, like where his mouth is and how they would make Hank speak.
There are certainly significant computational and algorithmic challenges, but at a more basic level, differing applications driving the quest for orthologs has led to differing definitions of orthology (particularly with respect to subcategories, such as in-paralogs or co-orthologs), the use of different source datasets and different metrics for evaluating performance.
There is a more basic problem.
The state's health department had a more basic concern.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com