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A more ambitious method involves aligning reads to a reference genome and using the alignments to infer the transcript structures, possibly with the aid of a curated transcript database.
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If cooling methods still represent the cornerstone of the heatstroke therapeutic approach, the magnitude of heat-related deaths and the morbidity associated with the August 2003 French heatwave have highlighted the need for more ambitious methods of treatment.
While pollsters and others have long sought to track the anarchic flight of our national whimsy, Rapaille's refinement of Dichter's method has a more ambitious goal, which he compares to a psychoanalytic human genome project.
It has been customary to tackle this problem by means of approximate model independent methods while a more ambitious alternative is to study the inflationary scenarios one by one.
He then offered a more ambitious idea.
He should be given a more ambitious assignment.
A more ambitious deal was probably politically impossible.
The final piece, "Middlegame," is a more ambitious, messier affair.
Gilbert then set about organizing a more ambitious colonizing expedition.
Or, anyway, a more ambitious one.
It's hard to imagine a more ambitious title for a book.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com