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Rather, clinical trials are part of a more active process of learning that allows pharmaceutical innovations to be useful outside the laboratory.
Considering the ability of EDTA and DTPA to remove Ln ions from the particles and the fact of minimal ion release in the presence of PBS buffer, we infer that the ion loss is a more active process involving the EDTA or DTPA molecules.
We are trying to think of ways to make that a more active process.
Viewing pictures of a romantic partner is likely to be a more active process than the simple, passive experience of a rewarding state.
Thus, ovary development is likely to be a more active process than originally thought, and disruption of genes in this cascade may lead to complete or partial transdifferentiation of ovarian tissue into testis (e.g. testicular DSD (Disorder of Sex Development) ["XX males"], ovotesticular DSD ["46,XX true hermaphrodites"], respectively).
Whatever the reason it is possible that a more active process of supervision might address these failings.
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For many years, testis development was believed to be the more active process.
PLS may be a more active pathological process than its rate of clinical deterioration implies, and this study supports the view that it has a distinct pathogenesis.
A more active inflammatory process in severely affected dogs, at least partly due to CD49dhi-expressing T-cell migration to muscles, could negatively impact ambulation either directly by inducing muscle pain, or by leading to increased muscle fibrosis, as described in affected individuals with more severe clinical presentations (Desguerre et al., 2009b).
Given the slower progression of disease in PLS, this was unexpected but may provide evidence for PLS as a more active pathological process than is clinically obvious, or reflect the relative 'reserve' of unaffected white matter compared to a decimated pathological landscape in ALS.
Another interesting finding of our study was the fact that RDW was positively associated with the Fuhrman grade in clear cell carcinoma in the general trend; this particular finding was in accordance with the rationale of elevation of RDW according to the presence of a more active inflammatory process, as a higher tumor grade generally enhances the local and systematic inflammatory reaction [ 33].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com