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Two variants within the NOS1AP gene were associated with a modified effect of the drug on QT interval duration in users of verapamil and, to a lesser degree, diltiazem [ 71].
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This contradicts our finding of a modifying effect associated with the RAD51-135c variant.
However, there was a tendency towards a modifying effect of ancestry in the circumcision prostate cancer relationship.
36 We also demonstrate a modifying effect by sun exposure on back naevus count among those carrying rs12203952 T (Fig. 1).
Although cigarette smoking was not associated with CCA development in the previous studies conducted in Thailand 12 17–20 and elsewhere, 21 a modifying effect by DNA repair genes remains a possibility.
Moreover, in this trial, a statistically significant decrease in matrix metalloproteinase enzyme serum level suggests that, in addition to the observed symptomatic effect, such a compound might have a disease modifying effect in osteoarthritis.
This has been interpreted to suggest that donepezil treatment for 6 months has a symptomatic effect, but not a "disease modifying" effect.
In the present study, we examined (A) the association between UACR and cognitive performance in Korean adults and (B) a disease modifying effect of APOE E4, a well-known genetic risk marker of dementia, on this association.
We conducted a systematic review to find evidence for our hypothesis that statin treatment has a disease modifying effect in patients with COPD and improves a) morbidity and b) mortality.
The present study was designed to test the hypothesis that this capacity would increase further after 1 year of vildagliptin treatment and that, if the increased capacity was due to a disease modifying effect on beta cell mass, it would still be present after a 3 month washout.
This is the minimum duration of treatment necessary to demonstrate a disease modifying effect.
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