The ST level was measured at the first ECT treatment session using a modified dose titration method [ 10].
In a subsequent phase 2 study in previously treated patients with HCC and Child-Pugh A cirrhosis, the tivantinib dose was reduced to 240 mg BID and a modified dose-reduction schema was implemented because of grade 3 or greater neutropaenia (Santoro et al, 2012).
Strategies introduced to improve the tolerability of topical treatments include modified dosing schedules, reduced concentration of the pharmacologic agent, and novel formulations.
The modified dose-titration method, starting with a low dose of Axona, decreased gastrointestinal adverse effects in Japanese patients.
One third of patients in group A developed hematological adverse effects and had required modified doses during antiviral therapy.
The modified dose-titration method, starting with a low dose of Axona (10 g, containing 5 g of C8), reduced adverse effects (such as diarrhea) in Japanese patients.
Column studies with variable operating conditions (initial fluoride concentration, bed depth, flow rate) and modeling of the breakthrough curves showed modified dose response model in excellent agreement with a maximum uptake of 1.12 ± 0.025 mg/g.
Based on the previous findings showing a direct relationship between pupillary responsiveness and serum retinol concentration [ 8, 14, 15] and modified dose response [ 8], the PFDA is currently undergoing validation as a tool to screen populations for vitamin A deficiency.
The microcolumn data were fitted by the Thomas model, the modified Dose model and the BDST model.
The control rate of doubling of titres was estimated to be 50%, and it was hypothesized that the modified doses of vaccine would improve the proportion of those doubling titre levels to 75%, an improvement of 25%.
