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The existence of the language in the bracket "(not including a modification to the structure of the biological product)"--actually does create a huge evergreening loophole.
If you look closely at the tricky language of the sentence you will see that changes to biologics that result in new indications, routes, dosing schedules, delivery systems, strengths, etc., are ineligible for another 12- year exclusivity period under the Eshoo approach only if they come about without a modification to the structure of the product.
There is in fact an 'anti-evergreening' clause which explicitly provides no new exclusivity period would be granted for "a change (not including a modification to the structure of the biological product) that results in a new indication, route of administration, dosing schedule, dosage form, delivery system, delivery device, or strength".
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In summary, among our sample of PLWH, we observed that more of the items on the Social Capital Scale appeared to represent a subscale of friends and family connections, followed by participation in the local community, which suggests a modification to the factor structure for anyone wishing to explore the individual factors or subscales in this population in the future.
This integration has been demonstrated with three device types: (A) a hybrid structure with embedded SU-8 waveguides and polydimethylsiloxane (PDMS) channels; (B) a structure using only SU-8 for both the waveguides and microchannel walls and (C) a structure as a modification to the all-SU-8 structure.
"The focus of the civic authorities is not on safety but on checking who is making a small modification to the structure, so that they can pressure the person to pay a bribe," said Rahul Srivastava, the other co-founder of URBZ.
A modification to the hash table data structure might allow storage nodes to dynamically update their active hash table region, and redirect overexpressed seeds to less heavily loaded storage nodes.
Intuitively, a mark is some local modification to the structure of a process for example, a scuff on the surface of a baseball or a dent an automobile fender.
The inverse problem of assigning natural frequencies and antiresonances by a modification to the stiffness, mass and damping of a structure is addressed.
The second modification to the structure was carried out by imposing a partial periodicity on the structure.
To enable the addition of a common syndrome considerable modifications to the structure of the Distribute system were required.
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