The phrase "a modification of target" is correct and usable in written English.
It can be used in contexts where you are discussing changes or adjustments made to a specific goal or objective.
Example: "The team proposed a modification of target to better align with the new market conditions."
Alternatives: "an adjustment to the target" or "a change in the target".
The most common mechanism of resistance in clinical isolates is a modification of the target site encoded by the cyp51A gene leading to reduced binding of the drug [2], [3], [10], [11].
This recently developed technique can be regarded as a modification of the target method whereby, instead of stationary traps or screens, insecticide-treated domestic animals, primarily cattle, are used as attractive, mobile, living targets (FAO 1988).
It is also unlikely that enhanced resistance in TAhab cells would be due to a modification of the inhibitors' target, since each inhibitor is thought to perturb cellulose synthesis by targeting specific molecules, with IXB possibly targeting CESA subunits 3 and 6 [ 13, 14], and DCB proposed to target either a small protein of 12-18 kD [ 41] or the microtubule-associated protein MAP20 [ 42].
The 2 main mechanisms of quinolone resistance are chromosomally encoded, either a modification of the quinolone targets with changes of DNA gyrase (gyrA) and/or of topoisomerase IV (parC) genes; or a decreased intracellular concentration due to impermeability of the membrane or to overexpression of efflux pump systems (2 ).
The Fbn1mgΔloxPneo targeting vector was a modification of the previously described targeting vector used to create the mgΔ and mgR models [11], [17].
One result of this idea was the AQM-34 Firebee, a modification of a standard U.S. target drone built in various versions since about 1951 by the Ryan Aeronautical Company.
The HU sensitivities of pmt3-K14R and pmt3-K14R,K30R are significantly less than that observed for hus5-62, indicathat thas as well as a requirement for SUMO chains, modification of target proteins by single SUMO/Pmt3 moieties is also likely to be necessary for the response to S phase arrest.
Drug treatment appeared to delay recruitment as evidenced by the reduction in the heavy polysome peak (≥ 6 ribosomes: compare Figure 1B and 1C), and this effect was correlated with a modification of the downstream signalling targets of mTOR, including 4E-BP1 and S6 kinase.
The UPS is a highly regulated process under the control of E1 (ubiquitin-activating enzyme), E2 (Ub conjugating enzyme) and E3 (ubiquitin ligase) enzymes, each playing a specific role in post-translational modification of target proteins (Deshaies and Joazeiro, 2009).
