Serine and threonines within specific effector proteins are acetylated by the plague bacterial enzyme YopJ, a modification involved in pathogenicity [4].
This mutation elicits an internal deletion of 50 amino acids in the carboxyl-terminus of prelamin A. The truncated protein, progerin, retains a farnesylated cysteine at its carboxyl terminus, a modification involved in HGPS pathogenesis.
c-Cbl is known to be an E3-ubiquitinating enzyme for attaching multiple mono-ubiquitin moieties to the cytoplasmic domain of EGFR, a modification involved in endocytosis and subsequent sorting of internalized receptor to MVB (Rubin et al, 2005; Citri and Yarden, 2006).
Sec bodies are novel stress structures and we have shown that they are not autophagosomes (or substrates of autophagy), not lipid droplets and not CUPS as they are devoid of dGRASP that is found quantitatively re-distributed in the cytoplasm upon amino-acid starvation, suggesting a modification involving its lipid anchor or modification of its N-terminus.
Specifically, we followed simultaneously two genotypes in a modified MCMC approach, where the criterion for accepting a genotype modification involved not only viability, but also the requirement that the Hamming distance to the other genotype be non-decreasing.
Phosphorylation is a key modification involved in signal transduction, and thus participates in many of the dynamic processes of the cell.
Specifically, H4K16ac, a histone modification involved in chromatin decompaction, is increased on nascent chromatin upon abolishing Hdacs1,2 activities.
K27-linked polyubiquitination was reported to be a unique modification involved in antiviral immunity (Arimoto et al, 2010).
Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor- β (TGF- β ) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN).
Our results showed that the expression of MLH1, one of the important MMR proteins, was decreased early and maintained the downregulation during the transformation in a histone modification involved and DNA methylation-independent manner.
STX1 is phosphorylated at Ser14 by the kinase CK2 (Hirling and Scheller, 1996, Foletti et al., 2000), a posttranslational modification involved in the functional regulation of STX1 (Khelashvili et al., 2012, Dubois et al., 2002).
