If six months doesn't sound like a lot, consider the economic incentive here: for the price of a modest clinical trial in children (costing at most $3 million), Schering can extend the life of its basic patent half a year and earn close to $1billion.
With the modest trial selection parameters chosen here, almost all patients who tolerated full-course treatment had preserved weight and performance status, and controlled pain over the study period (not shown).
However, there was also a modest reduction in trial-to-trial failure rates after SWE-induced plasticity if compared with the undeprived control, and this was also found to be stimulus intensity-dependent (Fig. 5A and B).
Analyses of time to progression or response rate surrogate endpoints, measures that do not include a survival in the surrogate, report more modest trial-level associations.
Places lets them signal where they are to their friends on the network, in much the same way that they can "tag" themselves in photos.Several advertisers have already run modest trials on location-based social networks.
"Indeed, in both monkeys a modest number of trials exhibited such spontaneous vacillations… we identified trials in which the decoder initially produced a value indicating one choice, then underwent a large swing to indicate the opposite choice".
A likely explanation is that we only had a modest number of trials per condition (24), as well as a wide variety of pictures that differed in terms of identification difficulty.
Indeed, in both monkeys a modest number of trials exhibited such spontaneous vacillations.
The following sentence, in the Results: "in both monkeys, a modest number of trials exhibited spontaneous vacillations".
Nevertheless, it is important to bear in mind that in the presence of a modest number of trials, as in the current review, these tests have limited statistical power in detecting bias.
