The phrase "a modest selectivity" is correct and usable in written English.
It can be used to describe a level of selectivity that is not extreme or excessive, often in contexts related to choices, preferences, or criteria.
Example: "The study employed a modest selectivity in its sampling methods to ensure a diverse representation of participants."
Alternatives: "a slight selectivity" or "a limited selectivity".
Detailed characterisation of members of the hexose transporter family is limited to SGLT1, 2 and 3, which are all inhibited in a competitive manner by phlorizin, a natural dihydrocholine glucoside, that exhibits modest selectivity towards SGLT2 (see 142 for an extensive review).
NBI-59159 is a non-substrate inhibitor with modest selectivity for EAAT3 over EAAT1 (>10-fold) and EAAT2 (5-fold) 43, 44.
Furthermore, profiling other members of this series identified compounds with >20-fold selectivity over PARP5a/TNKS1, and modest selectivity over PARP10, a closely related mono- ADP-ribosyl transferase.
One related compound, DBS (51), was identified as a 2.9 μM enzyme inhibitor, with modest selectivity over the human PyK [IC50 of 8 and 16.3 μM for human tissue HsRPyK (from erythrocyte) and HsM2PyK (from embryonic or tumor cells), respectively].
Further, the methyl analog showed modest selectivity for the ERβ receptor in an ER gene expression array panel, while the naphthyl analog did not significantly alter gene expression.
Whereas all three compounds stabilize UbG76V-GFP, cause accumulation of ubiquitin conjugates, and inhibit degradation of an ERAD substrate, DBeQ and ML240 also cause accumulation of LC3-II (indicative of a block to autophagy) and induce rapid cell death (with modest selectivity for transformed cells), whereas ML241 does not.
A binding protein for secretory phospholipase A2 has been identified which shows modest selectivity for sPLA2-1B over sPLA2-2A, alsoalso binds snake toxin phospholipase A2 216.
As a rule, threonine aldolases are very stereoselective for α-carbon configuration but show modest selectivity at the β-carbon.
The modest selectivity of the synthesized inhibitors was reasonably well predicted, although a correct ranking of the relative affinities was not successful in all cases.
