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There was a modest orientation bias against purine-rich sequences in the same orientation as the gene (Additional file 1: Figure S3b), indicating that most but not all genes tolerate an RNA DNA hybrid with the RNA on the transcribed strand.
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In essence, scaffold proteins represent a subclass of hubs that, being characterized by a modest number of interacting partners, provide selective spatial orientation and temporal coordination to facilitate interactions among bound partners.
The structural analysis of these FKBP12 variants support the possibility that there may be only a modest energy difference between the canonical and the perpendicular orientations for the indole ring of Trp in the wild-type protein.
Take a modest proposal.
Some earn a modest pension.
He has a modest ambition".
Here's a modest proposal.
A modest little house designed.
It had a modest impact.
It is a modest proposition.
A modest backlash was inevitable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com