Finally, there was a modest interaction between the bin values of the more contemporary movies (1990 2015) and those of these midrange movies (1960 1985; F[11,996]96] = 5.32, p = .02).02
In previously published analyses, a modest interaction was observed for the outcome of total mortality between the intensive glycemia and BP interventions (P = 0.03); the group that received both intensive interventions had the highest mortality, while the groups receiving either or both standard interventions had lower mortality (Supplemental Fig. 4 in 11).
Our simulations contained a modest interaction effect (h2 = 0.05) in the presence of very small main effects (h2 = 0.01) at each of the interacting genetic variants.
We did observe a modest interaction between BMI and rs8050136 (FTO) (uncorrected interaction p value = 0.03).
Although their effects are quite modest, interactions of genotypes with exposures, birth cohort effects, reproductive factors, and interventions such as RRSO may provide significant information about risk.
However, in our study, where NOS2 was the gene of interest, we found no interaction between LPS and FK565 in macrophages, and only a very modest interaction in VSM cells.
The two α-helices are positioned roughly perpendicular to the duplex DNA axis, forming a modest CarD/DNA interaction surface of 380 Å. 10.7554/eLife.08505.012 Figure 2. CarD-CTD/promoter DNA interactions.
The half maximal inhibitory concentration value of BMS-911543 in incubations with tacrine as the CYP1A2 activity probe did show a modest level of interaction with the enzyme, however, detailed study of enzyme kinetics or the potential for CYP1A2 time-dependent inhibition was not explored before clinical studies.
Interactions between a history of smoking and HLA-SE in the risk for seropositive RA has been demonstrated in several previous reports in early RA, the first one in 2006 [ 7], A modest additive interaction between a history of smoking and HLA-SE in the risk for development of seropositive RA was shown in analyses from the Nurses Health Studyy by Karlson et al. [ 12].
This resulted in the detection of a modest synergistic interaction between AKT3 rs2125230-PRKCQ rs571715 (p = 0.011), as shown in Table 4. Based on MDR, this model was the best two-factor model.
