Response rates to vascular targeting agents in AML have been modest; however, a majority of vascular targeting trials in AML are monotherapy in design and indiscriminate in patient recruitment.
The benefit seen in the early combined-modality trials was modest, however, with a median survival of only 10 months.
The study size was modest however, and a larger trial powered for clinical outcomes is required to confirm these physiological changes and determine whether they translate into improved clinical outcomes.
The CBS telecast of the Tonys leaned heavily on celebrity appearances; the ratings were modest, however, with an average of just over 7 million viewers, compared to 7.4 million last year.
With a market capitalisation of some $130 billion, a modest investment, however good, simply will not "move the needle".
On a modest agenda, however, CableSoft Corp. has made it work.
The effect of MDD on mortality appears to be a modest one, however, with a relative risk of approximately 1.4 [ 10].
A modest risk, however, does not preclude a causal association and may reflect a lower level of exposure, an agent of lower potency, or a common disease (e.g., when there is a relatively high incidence rate of a disease in the general population, it is more difficult to reach a doubling of that incidence rate).
With regard to the IGFBP-3, the ORs suggest a decreased risk for men in the lowest quartile and a modest trend; however, only men in the third quartile were at significantly increased risk compared with men in the lowest quartile (OR=2.46; 95% CI=1.15 5.27), and the trend test was not significant.
Ford's expectations were relatively modest, however.
Gains in other areas have been modest, however.
