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The panel rated two types of treatment, one focused on memory and the other on social skills, as having a "modest" evidence base.
However, only a modest evidence for association between body mass index (BMI) and the PCSK1 variant rs6232 (P = 0.03) was found in a meta-analysis of 15 genome-wide association studies (GWAS) for BMI with 32,387 individuals of European origin [5].
For RA; PRKCQ and GZMB (these showed nominal significance P<10−4 to 10−5 in the WTCCC study), IL2RA, IL2RB and TNFAIP3 (these showed a modest evidence of association P<10−5 to 5×10−7 in WTCCC study), and MICA [29] [31] as well as IRF5 [33], [33] that was confirmed by meta-analysis [34].
All three agents have received a strong recommendation for use in FM from the more recent pharmacological treatment guidelines 16– 19 and a modest evidence for efficacy rating from the older American Pain Society 2005 guideline.
In our study, there was only a modest evidence of significant changes in tumour dimensions after 14 days of treatment, maybe due to the short interval between the two evaluations.
74 A recent study by Cordell et al 75 using whole genome scan in primary, nonsyndromic vesicoureteric reflux revealed a modest evidence of linkage but no clear overlap with previous studies.
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As a consequence, a decision needs to be made at an early point in time whether evidence based on surrogates will be acceptable: for example, whether there is the potential for major health gains by introducing a biomarker with only modest evidence to support its use, or whether a hard endpoint must be assessed before implementation.
A program called Moving to Opportunity, which was initially judged a failure, now provides modest evidence that removing children from high-poverty neighborhoods can have lasting positive effects on their lifetime earnings.
A third novel locus with a LOD score of 4.05 on chromosome 12q24 was detected in a subset of the data, and we also obtained modest evidence for a previously reported interval on chromosome 4q22-25.
Chris Dyett at Investec said: A solid update, slightly ahead of our expectations, with only modest evidence for a bear attack on minerals growth rates which were always going to slow.
Codd et al. (2013) showed modest evidence for an effect of a polygenic score based on the 7 genome-wide significant telomere-associated SNPs identified in their meta-analysis with coronary artery disease (p = 0.014, from a study of over 22,000 cases and 64,000 controls).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com