Thus, a modest alteration of RYGB criteria to include this population would have far-reaching implications for diabetes care.
This demonstrates that even modest alteration to the molecule indeed can increase antibiotic efficacy.
Even with very high fructose supplementation, there is only a modest alteration of hepatic glucose metabolism, which may merely represent a metabolic adaptation to the consumption of a glycogenic substrate rather than a step toward diabetes.
We find that a modest alteration of an initially 'scale-free' network can usefully improve robustness against attack, particularly when the fraction of attacked nodes is small, and we identify modification schemes that are most effective for this purpose.
The single-dose level of PPARpan induced a modest alteration in gene expression.
No significant effect of the combination was noted in any of the cell lines tested, with the exception of the wt-MCF7 in the presence of E2, which showed a modest alteration that just barely met statistically significance (Additional file 3: Figure S3).
After a panic at the turn of the millennium about the impact on their industry of online shopping, bricks-and-mortar stores settled into making only modest alterations to their business model or, ostrich-like, trying to ignore it.
We expected that the reduced or absent levels of miR-279, miR-317, and miR-184 in the mutant females would, to some extent, mimic the down-regulation that we had previously observed following receipt of SP. Our observation of modest alterations to SP responses in the miRNA mutant females suggests that the miRNAs may function to buffer noise or stabilize responses to mating.
Nevertheless, a more modest alteration of the CLR RAMP1 interface could be envisaged that results in an allosteric modification of the peptide-binding site (Fig. 3A), with compounds such as BIBN4096BS and MK-0974 asting as a lever between the N-termini of RAMP1 and CLR, breaking nearby interactions which are critical for binding of the peptidic ligand.
By this view, the protein world ought to consist of one structural archetype put to many different uses, each involving modest alteration of peripheral structure but no major reorganization of the fold.
Such substantial changes would be predicted to be especially relevant for staple crops because the high consumption means even modest alteration in phytonutrients will have a dietary impact.
