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Only patients 1 and 6 showed a moderate decrease in the level of PaCO2 (Table 1).
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Single-agent trastuzumab at 1 μg/ml resulted in a moderate decrease in total levels of HER2, and, as expected, a more significant decrease in HER2 activity as reflected by the level of HER2 autophosphorylation.
There was a moderate decrease in plasma cholesterol levels, and no change in hepatic LDLr, SR-BI, andG5/G8 and CYP7A1 expression.
ER- cell line MDA-MB-231 showed a moderate decrease in E2F2 transcript levels at 48 and 72 hours.
Sulindac sulphide treatment led to only a moderate decrease in total β-catenin levels.
Consistent with this was a moderate decrease in mean plasma HCY levels among seniors by 1.3 μmol/L.
Even a moderate decrease in tissue ascorbate content, to levels still considered adequate for normal health, had a significant impact on tumor pathology.
Inhibition of CDK2 by roscovitine or CDK2 inhibitor was associated with a marked decrease in cyclin D1 protein levels in HCT116, a moderate decrease in MCF-7, but no change in PC3.
Some clinical statistics showed a moderate decrease in compulsory admissions, and an increase in civil commitments, which reached a plateau on a high level.
In line with this, a severe reduction in endogenous strigolactone levels due to mutations in ccd7 or ccd8 is linked to a moderate decrease in nodulation efficiency [ 2– 4].
Changes in Beclin 1 levels were functionally relevant because a moderate increase in Beclin 1 expression markedly facilitated CD40-induced killing of T. gondii while a moderate decrease in Beclin 1 expression profoundly inhibited this response.
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