The phrase "a model of dormancy" is correct and usable in written English.
It can be used to describe something that exemplifies or represents a state of inactivity or rest.
Example: "The research highlighted a model of dormancy in certain plant species during extreme weather conditions."
Alternatives: "an example of dormancy" or "a representation of dormancy".
The appearance of the lipid loaded Mtb cells from the multiple-stress in vitro model of dormancy was very similar to that of the dormant Mtb cells from human patients [35].
In the widely used Wayne model of dormancy based on hypoxia, the maximum phenotypic Rif-resistance obtained against a very low concentration of Rif (0.1 µg/ml) was about 21% after 8 days and gradually decreased to 17% tolerance after 14 days and to 12% after 22 days [24].
This model is entirely consistent with the clinical model of dormancy proposed by Demicheli (see Figure 4 in [ 7]).
In another 3D model of dormancy, using several breast cancer cell lines that exhibit dormancy in lungs of xenografted mice, the transition from quiescence to proliferation was found to be dependent on fibronectin production, signaling through β1 integrin, cytoskeletal reorganisation and the formation of actin stress fibers [ 48].
Mycobacterial behaviour within adipocytes may be interesting to further investigate as a model of persistence, as compared to other currently used in vitro models of mycobacterial dormancy.
The long interval between treatment and recurrence is inconsistent with a model of continuous growth of cancer cells [ 11- 15], but instead suggests a state of tumor dormancy [ 16].
In a mouse model of tumor dormancy, enhanced B7-H1 expressinn in dormant tumor cells enables long-term persistence of these cells through inhibition of CTL-mediated killing [ 4– 6].
Because DevR regulon induction occurred early and preceded the cessation of mycobacterial replication, AA could have potentiated the adaptation of actively growing bacteria to a stage of growth arrest, similar to that observed in other hypoxia-based models of dormancy.
Paper: "The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy" Podcast: "Whitehead's Robert Weinberg on cancer research's past, present, and future" Article: "Variations in cell programs control cancer and normal stem cells" Article: "Scientists identify gene that controls aggressiveness in breast cancer cells".
In vitro models of dormancy have identified hypoxia, nitric oxide (NO) and nutrient starvation as dormancy inducing signals [4] [6].
