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Utilizing the active opsin structure in complex with a transducin peptide [35], [36] and the consequential orientation between receptor and G-protein, we initially built a model of activated TSHR that is bound with heterotrimeric Gq.
These observations are consistent with a model of activated transcription in which H1 displacement is an early event in transcriptional initiation.
To directly assess the ability of macrophages to utilize the superoxide/NO* → peroxynitrite oxidative system in SWCNT biodegradation, we utilized a model of activated THP-1 macrophages known to generate peroxynitrite upon stimulation with phorbol 12-myristate 13-acetate (PMA).
More than two decades ago, 99mTc-labeled Nocardia soluble peptidoglycan derivative (which can bind to a model of activated macrophages) was evaluated for scintigraphic detection of melanoma metastasis (Le Pape et al 1986).
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PDB structure 2A8J (chain A) served as the template for construction of a homology model of activated Taspase1.
Finally, a qualitative model of activated electrons transport based on an hopping mechanism was proposed in order to take into account that the Arrhenius diagrams of both total conductivity and dispersion factor are characterized by a break point with two activation energy values.
This approach was guided by a homology model of activated TSHR in complex with heterotrimeric Gq, using the X-ray structure of opsin with a bound G-protein peptide as a structural template.
As Cav-1 stromal cells are a genetic model of activated myofibroblasts [ 2] which biosynthetically secrete more collagen, and fibrosis is a critical risk factor for poor clinical outcome in human breast cancer patients [ 3], we also looked at the potential overlap been the expression of collagen gene transcripts (See Table 1).
We investigated whether gluconeogenic signals directly control Hepcidin, an important regulator of iron homeostasis, in starving mice (a model of persistently activated gluconeogenesis and insulin resistance).
We designed a dual-mode experimental setup for confocal endomicroscopic imaging and fluorescence lifetime measurement and applied it to a mouse xenograft model of activated human pancreatic cancer generated by subcutaneous injection of AsPC-1 tumor cells.
We suggest that although subcellular domains or lipid platforms may increase local concentrations to enhance oligomerization our data clearly does not support a simple domain accumulation model of activated dimers in the absence of higher-order oligomerization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com