We can't use the efficacy of a drug in a xenograft model in mice as evidence to measure whether a cell-culture model has worked because, in some contexts, a cell-culture model might allow the architecture of the tumour to be recapitulated better than a subcutaneous xenograft model.
While grand visions of transforming the agricultural system are difficult to implement wholesale, a regionally-centred model might allow more concrete engagement with existing agricultural practices and appropriate avenues for innovation to meet multiple needs (food, fuel including for farming, waste management, biodiversity).
The model might allow the study of the pathophysiology of autoimmune hepatitis and viral hepatitis.
Importantly, our model might allow to possibly unlock fundamental mechanisms of regeneration that could be used in the future to also repair adult hearts.
Therefore the model might allow further studies clarifying these crucial steps of angiogenesis and tumor invasion and metastasis which are promising targets for new drugs against solid tumors [ 52, 53].
Thus, the high tumor incidence (100%) and convenience of chemical treatment in this inducible model might allow it to be used for detailed analyses of liver tumor progression and/or regression as well as for potential anti-cancer drug screens.
Alternative models might allow for a sigmoidal growth in the probability for infection, i.e., the probability of infection increases monotonically; however, the rate of change first increases to a maximum and then decreases steadily to zero.
From the perspective of our results, adding geology, elevation, and landforms to the models might allow for more realistic results and in many cases narrower predictions of suitable habitat.
Simulations of these phenomena in computational models might allow further reconciliation of the results of these types of studies.
Better predictive models might allow appropriate targeting of cumbersome or costly preventative interventions and enhance the power of clinical studies examining such interventions.
