Furthermore, a small sample size can frequently result in insufficient power to detect minor contributions of one or more alleles [ 30] – as we observed with the results from the SEARCH sample.
When would a small sample size be problematic?
Although a small sample size, he was far from alone.
That's an 89% completion rate, and not over a small sample size.
It is a small sample size to be sure, but a good start nevertheless.
TC: This is a fairly small sample size.
Due to the small sample size of the minor homozygote AA genotype patients who had a positive culture (SPH AA genotype; Gram-positive n = 5, Gram-negative n = 8, fungus n = 0, mixed n = 1, total n = 14), we compared AA+AG genotype versus GG genotype in this analysis.
Due to small sample size for hospitalizations with minor illness severity, the categories for minor and moderate illness severity were combined for the analyses and referred to as minor-moderate illness severity.
For the MRE11A gene differences in LD structure were noted, however, these were minor and likely attributable to small sample size since the differences were driven by 3 rare haplotypes (frequency = 0.02).
Although the number of GWASs has grown dramatically during the last five years [ 36, 37], GWASs have several limitations, such as small sample size, dependence on minor allele frequency and genetic effects, stringent statistical significance, and the difficulty of replication across studies [ 38].
