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The one metastatic melanoma patient had a minor response during the study period.
A minor response was observed in 2 of 24 patients with recurrent glioblastoma receiving CpG-28 in a phase I trial.
"It just seems to me wrong to a patient if you've received a minor response rather than a partial response that you can't go on and receive treatment," said Dr. Paul S. Richardson, a researcher at the Dana-Farber Cancer Institute in Boston.
Four patients had a partial response, and two had a minor response.
None of the patients achieved a partial or complete response; however, 3 patients achieved a minor response and 14 had stable disease.
At the end of induction, 14/22 (64%) of patients had an objective antitumor response: three patients had a complete response, ten patients had a partial response (greater than or equal to 50% resolution of clinical disease), and one patient had a minor response.
Without cooperativity (q = 1), there was no sensing of the gradient, and instead there was a minor response to the internal cue, which was to the left.
As it can be expected following the EnvB immunization, a strong response against a homologous gp120 protein was detected, whereas after the BF immunization a minor response was found (Fig. 7C).
A minor response was achieved in four (11%) patients.
If the decrease is less than 500 ng mL−1, a minor response (MiR) is reached.
An additional 18 women showed a minor response or no change.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com