However, only one minor refinement, the addition of a question about impact on life roles, was added after the first three interviews.
Sequence alignment of K-rich domains of STIM proteins from representative species was performed using Clustal Omega, followed by a minor manual refinement.
What we can expect now: pedagogical backtracking, coupled with loud insistence that it's just minor refinement and no harm was done.
Another month of discussion and relatively minor refinement followed, during which several attempts were made to alter the Rutledge draft, though few were successful.
In addition, findings from qualitative interviews with dentists, child participants and their parents on their views of participation in the Rehearsal Trial [ 15] have been used to inform improvements in the conduct and minor refinement to the design of the trial.
Despite some turnover among organizers and participants, the methods have remained consistent for more than a decade, aside from minor refinements in the data forms and training.
To my hand, it felt like a prototype — an untested design that needs real change as well as minor refinements like button shape.
And while major pharmaceutical companies claim an average of three new drugs a year, many of them are me-too's or minor refinements of existing therapies.
During the early tailbud stage (Figure 2C) they underwent only minor refinements in their position relative to their neighbors before adopting a final and invariant position that was retained throughout the mid and late tailbud stages (Figure 2D,E; Movie S2).
A few years later, the VCR, MP3 player or netbook reaches its final form, with only minor refinements in the years to come.
