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Surprisingly, in contrast to the dynamic gene expression pattern observed in RNAPII ChIP-seq and RNA-seq analyses (Fig 1C), the number of p63 binding sites and the p63 binding signals only showed a minor overall decrease during differentiation (Fig 2A; Supplementary Fig S4B).
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Likewise, inactivation of the Rtt109 acetyltransferase had a minor overall effect on the transcriptome, as only 72 transcripts were decreased 1.5-fold or more compared to WT at an FDR < 0.1 (Lenstra et al., 2011).
However, carriers of mutations that cause a minor decrease in overall telomerase activity were shown to cause significant reduction of telomere length over generations that will eventually lead to telomere syndromes [ 55, 56, 59].
CB: Well, we've experienced a dramatic overall decrease in violent crime.
Thus, there was a net overall decrease in employee morale.
"It brings an overall decrease in violence".
Recent surveys in schools also suggest an overall decrease in drug experimentation.
The president's latest budget calls for an overall decrease in federal support for elementary and secondary education.
General Motors remained the largest American advertiser despite an overall decrease of 2.5percentto to $2.88 billion in 2000 from $2.96 billion in 1999.
Both components experience an overall decrease downhole.
However, the figures show an overall decrease in council payouts.
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CEO of Professional Science Editing for Scientists @ prosciediting.com