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Incorporation of a minor dose of 4-vinylpyridine (4-VP) into an end segment of polystyrene (PS) chain by emulsion copolymerization yields a copolymer molecule P 4-VP/S) with weak surface-activity.
The results were consistent with the effects on growth where a minor dose relation was observed with docetaxel whereas a major dose relation was observed with doxorubicin (Table 1).
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Another three patients had minor dose reductions, because of toxicity and preference.
These were usually minor dose modifications or delays, most commonly resulting from 5FU-induced mucosal toxicity.
Chemotherapy according to the MUV-ATRT regimen was generally well tolerated and only minor dose adjustments and delays occurred.
Maximum expression of CCL2 mRNA was observed in the early phase; although there seems to be minor dose dependency, no statistically significant induction was observed (data not shown).
In both cell lines only minimal caspase-3 cleavage could be detected, worth mentioning is the minor dose response detectable for the curve shift to the right within Cal-78 cells.
Fortunately, the adverse effects due to drug drug interaction between cisplatin/carboplatin and most antiretroviral drugs that can be used in the treatment of patients with cervical cancer is mild though some may need minor dose adjustments as illustrated in The University of Liverpool HIV drug interactions website (www.hiv-druginteractions.org; accessed 21 October 2014).
A replication of the experiment presented in Figure 9A but with minor doses of OA (0.1 mM and 1 mM), revealed non facilitatory effect of OA [ANOVA F5,233 = 1,32; p = 0,25; planned comparisons, SAL: p = 0.21; OA 0.1 mM: p = 0.18 and OA 1 mM: p = 0.25], indicating that the effect of the amine is dose-dependent.
Anxiolytics and hypnotics in minor doses were permitted at the early stage of the study.
Given an incorporated activity of 200 Bq 68Ge per application of 200 MBq 68Ga-DOTATATE, a minor total effective dose of 0.1 μSv [31] is certainly not exceeded.
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