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Only those genes with a minimum observation of one mapped read across all individuals at all time-points were included.
After a minimum observation of 4 years and a maximum close to 13.5 years, estimated 6-year survival and DFS rates ranged from 73%and64%4% in CMR patients to 24%and15%5% in MR2 patients, respectively, mostly in relation with an increasing RI, except for CMR and MR groups.
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The analysis of the survival data was based on a minimum observation period of at least 15 months from the time of entry of the last patient.
The data collected are part of a larger study which will cover all of Italy with a minimum observation period of 10 years, after which, with a separate independent note and a proper statistical study, we will give an account of the results obtained.
Previous reviews have stipulated a minimum observation period of 3 months [3, 9] to 2 years [10].
Recently, a minimum observation period of at least 2 years was suggested to be required to detect any subtle global RNFL changes in MS patients without ON, if they exist at all [20].
A minimum observation time of 72 hours after cardiac arrest or a return to normothermia in hypothermic patients is required for evaluating individual patients [ 4].
7 The first 30 days after discharge were considered a buffer period to ensure that all patients had the chance to achieve clinical stability and obtain drug treatment, and to guarantee a minimum observation period of 1 month.
The following settings were used, in p.vector the Q value was set at 0.01 and multiple testing correction was performed by using Benjamini Hochberg with minimum observation of 20.
For simple univariate multinomial or logistic regression, Hosmer and Lemeshow [15] recommended a minimum observation-to-variable ratio of 10, but cautioned that a number this low will likely over-fit a model.
If there were no outliers and extreme values, the whiskers represented the maximum and the minimum observations of the dataset.
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