Normal mature hepatocytes and cholangiocytes stay in the G0 phase of the cell cycle, exhibit a quiescent phenotype and show minimal turnover, but in response to partial hepatectomy (PH), they can undergo cell proliferation to compensate for the lost cells, a process called liver regeneration.
As shown in Fig. 1C, the level of HA-Lys48-linked polyubiquitylated proteins remained relatively unchanged in A-T cells up to three hours in the presence of CHX (Fig. 1C, left panel, compare lanes 1 and 2), suggesting minimal turnover of Lys48-linked polyubiquitylated proteins in A-T cells.
Neller, M.A., Burrows, J.M., Rist, M.J., Miles, J.J. & Burrows, S.R. High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover.
As a bonus, the editors pick their top-ten ETFs based on diversification, low expenses and minimal turnover.
Groupthink often occurs in teams with minimal turnover.
Based on the ribonuclease activity assays, the minimal turnover numbers for GCN4 LZ35, c-Jun LZ36 and full-length c-Jun were 0.0024, 0.0033 and 0.0008 min−1, respectively (Table 2).
If there is only minimal turnover in the eye lens, the content of 14C in the lens crystallines should thus reflect the atmospheric concentration at the time the lens crystallines were formed.
There was also minimal turnover in the other direct care providers and physicians.
Conclusions from these experiments were limited because of minimal turnover of Tra1 after cycloheximide arrest.
Alternative estimates of 5MeC minimal turnover rates may be made, independent of the use of DNA methylation inhibitors, based on the approximately hour-long cycles of pS2/TFF1 transcript expression observed when this gene is induced in multiple cell types [ 20].
