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Current drugs are a far cry from even a minimal target profile developed for a new chemical entity (NCE).
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The field would benefit by reaching a consensus about the minimal target specificity and sensitivity of blood-based biomarkers for AD for these to be clinically useful in different diagnostic settings.
We chose a 90% response rate as the experimental target level and a 70% response rate as the minimal target level with α- and β-errors of 0.1, resulting in a target of 25 patients.
Given a required accuracy for spray deposits, the minimal target area can be derived.
As in other studies [ 1], it was suggested that quality control procedures for daily performance of tests in the clinical laboratory setting should not be ignored, and that a minimal performance target of coefficients of variation in EIA assays should be established [ 12].
This target has been designed to have minimal target density fluctuations under the heat load of a 20μA CW 854.3 MeV electron beam without rastering the electron beam.
Minimal target enteral caloric intake was 120 kcal/kg/day, minimal target enteral protein intake was 3.6 g/kg/day, with an optimal target of 4 g/kg/day.
The minimal target should be to get ready for manufacturing (including securing a supplier).
Nor will the package currently being discussed achieve the minimal target of centrist deficit hawks (myself among them), that of stabilizing the rate in which the national debt is growing in relation to the economy.
Only the total skeletal retention of [177Lu]DOTA MBP 2 increased to 64.5 ± 1.5 %ID but showed at the same time the minimal target to soft-tissue ratio.
In Experiments 2 and 3, we held contrast constant and we varied size, in order to establish the minimal target that could be discriminated for each of the two classes of cone.
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CEO of Professional Science Editing for Scientists @ prosciediting.com