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In the current sample, all subjects were myopes with a minimal progression of 0.30 D/year, and the relationship between the RPRE with the refractive correction was correlated with the amount of increase in the AL after 1 year of treatment.
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Other patients who demonstrate SD or a minimal disease progression might end up with extended long-term survival.
4 14 15 Especially since modern clinical trials show only minimal progression, disagreement between readers at the joint level may have a potentially important impact on the study results.
This was not the case for GO-FORWARD, as minimal progression was observed in all patients regardless of treatment.
At 52 weeks, the majority of patients exhibited no or minimal progression of structural damage (figure 3C).
5– 10 Thus, the expectation was that MRI would detect a difference among the GO-FORWARD treatment groups in the progression of bone erosion despite the fact that radiographic evaluation could not. 3 The fact that only minimal progression of bone erosion was observed even with MRI confirms that these patients did indeed have minimal progression in structural damage during the 6-month study period.
At week 104, the majority of patients demonstrated minimal progression of radiographic structural damage, with differences favouring the add-on group (table 2, figure 3A).
There was very minimal progression of radiological lucency from early postoperative period to the most recent follow-up in individual zones around the components.
The effect of golimumab on bone erosions could not be determined by semi-quantitative scoring in these RA patients with minimal progression of bone erosions.
This minimal progression precludes placebo-controlled trials and necessitates treatment groups of several hundred patients to ensure sufficient power to detect even modest treatment group differences.
In many studies, the hazard ratios showed a treatment effect on progression with minimal effect on survival (30%); fewer studies resulted in hazard ratios representing a minimal effect on progression with a more pronounced effect on survival (13%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com