The phrase "a minimal negative effect on" is correct and usable in written English.
It can be used when discussing the impact or consequences of an action, event, or decision that is slight or limited in a negative way.
Example: "The new policy has a minimal negative effect on employee productivity, as most workers have adapted quickly to the changes."
Alternatives: "a slight adverse impact on" or "a negligible negative influence on".
It is perplexing that the five-fold reduction in CD8 binding afforded by the A245V substitution can have a minimal negative effect on antigen recognition 18 while a 50% increase in binding confers such a positive effect.
When patients have non-life-threatening metastases that are suspected to be hormone sensitive (i.e., in breast cancer that is estrogen receptor [ER]- or progesterone receptor [PgR]-positive), it is desirable to continue endocrine therapy as long as possible, since the therapy itself has a minimal negative effect on the QOL [ 1].
Bioactivity results were normalized to a native protein sample and are presented in Figure 4. Native protein, in the absence of thiol ene monomer and LAP, maintained ∼95% of preirradiation activity, a result that indicates light exposure alone has minimal negative effect on the function of lysozyme.
External loading of JPW3027 is extremely simple and fast, and can be used to pre-select cells for further electrophysiological studies or to monitor the appearance and development of electrogenesis with minimal negative effect on culture health.
The development of biomass energy is relatively slow in China, but the new energy field has great potential because of its minimal negative effect on the environment, low cost of raw material, wide distribution of resources, and great energy conversion potential [ 14, 15].
Melatonin has emerged as a possible treatment to maintain the circadian rhythm with oral administration having good bioavailability, with minimal negative effects on respiration despite its hypnotic effects [99].
Melatonin has emerged as a possible treatment to maintain the circadian rhythm with oral administration having good bioavailability, with minimal negative effects on respiration despite its hypnotic effects [ 99].
Thus, it has been suggested that the steroidal agents have favourable end organ effects; for example, the steroidal inhibitor, exemestane, has minimal negative effects on bone and lipid metabolism in animal and clinical studies.
This paradigm depends on the availability of a low-cost intervention with no or minimal negative effects, such as efforts at reducing the prevalence of smoking.
Despite the minimal effect of maternal age on implantation after the transfer of a euploid embryo, a negative effect on delivery rates has been described by other authors.
In the case of cancer, complete surgical resection of neoplasia remains one of the most efficient therapies while postsurgical minimal residual disease has a negative effect on long-term outcome[2].
